Process Safety Management (PSM) is a comprehensive framework for preventing catastrophic incidents involving hazardous chemicals. In chemical manufacturing, oil & gas, and pharmaceutical plants – where toxic, flammable, or reactive materials are used – a robust PSM system is essential to protect workers, communities, and the environment. This whitepaper reviews the regulatory landscape (notably OSHA’s 29 CFR 1910.119), outlines core PSM program elements, examines case-study lessons from past incidents, and provides industry-specific guidance. Best practices include strong management commitment and safety culture, risk-based hazard analysis, integrated process safety information and procedures, thorough training, rigorous audits, and continuous improvement. Tables and figures summarize regulations and unique industry challenges.